Chemical profile and beneficial effect of standardized extract of Stevia rebaudiana Bertoni leaves on metabolic syndrome in high fat diet streptozotocin-induced diabetic rats
نویسندگان
چکیده
Abstract Stevia ( rebaudiana Bertoni) is a natural zero calorie sweetener with significant economic and medicinal values due to its high contents of steviosides (SVGs) in the leaves. The aqueous extract leaves (TAqE) was standardized contain 8.5% w/w SVGs (HPLC), total phenolics (164.63 ± 1.39 µg Gallic acid/mg extract) flavonoids 100.5 0.79 QE/mg extract. Twenty-one compounds were tentatively identified via UPLC-Orbitrap HRMS stevioside, rebaudioside A, quercetrin isolated from TAqE by repeated column chromatography. Stevioside showed inhibition pancreatic lipase, α-amylase, α-glucosidase enzymes. effect on fat diet (HFD)-streptozotocin (STZ)-induced diabetic rats investigated. Thirty-six animals divided into 6 groups (each 6). Rats group I (control) II (control/HFD-STZ) received distilled water, III IV for 4 weeks two doses; 300 mg/kg b.wt., 500 respectively. V metformin (200 mg/kg), while those VI statin (1 mg/kg). Body weight, fasting blood glucose, lipid profile (total cholesterol triglycerides), liver enzymes (alanine transaminase aspartic transaminase), serum kidney parameters (urea creatinine) decreased treated (300 b.wt.), insulin sensitivity enhanced, when compared that II. These findings could justify use as complementary medicine prevention treatment metabolic changes associated diabetes mellitus type 2.
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Now a day, various medicinal plants are becoming popular for the treatment of different diseases. Some medicinal plants are being used for the treatment of diabetes all over the world. The study was conducted to investigate the effects of powdered form of Stevia (Stevia rebaudiana Bertoni) leaves on blood glucose concentration and body weight in Streptozotocin induced diabetic rats and for its ...
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ژورنال
عنوان ژورنال: Applied Biological Chemistry
سال: 2022
ISSN: ['2468-0834', '2468-0842']
DOI: https://doi.org/10.1186/s13765-022-00724-8